Mode, the players' starting locations are hidden from each other, and provide bonus DNA as long as they remain undiscovered, each country also gives different starting DNA. The starting location mechanic differs slightly from the main game.
When both plagues have been eradicated at the same time. When a server connection error occurred. This will give the winning player a message the opposing player 'resigned'. This can be achieved by all host carriers of one plague to die off, one player being cured, or one of the player disconnects from the match once it begins. Successfully infecting everyone will result the player with the most infects to win and give both players a message that the winning plague has absorbed the losing plague. 
This includes the population that is also infected by the opposing player.
When a player manages to infect everyone in the world. For example the Pharmaphile gene will improve infectivity in rich countries but slow infection in poor countries. There are different genes on Multiplayer games, however they also create a disadvantage, as opposed to regular genes which only provide benefits. 
The player's plague will be colored red, and the opposing player will be colored yellow. Gameplay has been heavily altered with a lot of changes, such as the ability to force cure research to begin immediately. mode, players struggle for dominance over each other to win.
Mode is a game mode added in Evolution 15 of Plague Inc: Evolved.
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